Many patients suffer from unexplainable pain in the right upper abdomen or in the right upper back after a meal. I now detected a frequent reason for such complaints- a novel vascular compression syndrome.
In some patients the duodenal function is retarded or disturbed. Then , after the ingestion of food , the stomach empties large amounts of food into the duodenum. Now the descending portion of the duodenum progressively enlarges and exerts pressure onto the right renal vein. The vein is squeezed from above by the steadily distending duodenum and from below by the stiff right renal artery. The artery exerts a pulsatile pressure onto the right renal vein since the artery cannot move away because it lies on top of the lateral surface of the lumbar vertebra. This bony resistance with the artery on top presses the vein from below whereas the growing pressure from the distending duodenum presses the right renal vein from above. This causes a gradually increasing venous congestion of the right kidney which is felt as a growing pain in the right flank , in the right upper abdomen below the liver or in the right upper back.
I detected this condition in many patients in whom I meticulously observed the duodenal transport to rule out a Wilkie syndrome. The patients ingested tolerable amounts of food and fluid and then I started observing the transport in the descending and horizontal part of the duodenum.
In many patients an intermediate state exists resembling a low-grade Wilkie syndrome.
In other patients there is no narrowing of the passage between the aorta and the superior mesenteric artery, but an intrinsic deficiency of the duodenum and motor function does not allow a proper continuous transport of food from the pylorus across the descending portion of the duodenum and subsequently through the horizontal portion of the duodenum past the aortomesenteric fork.
These are relatively frequent conditions which do not fit in the pattern of a Wilkie syndrome and are often misdiagnosed as a gastroparesis. The gastroparesis is usually diagnosed with a scintigram showing a delayed emptying of the stomach. This is then interpreted as a decreased activity of the stomach. In fact, I never saw a decreased motor function of the stomach in these patients. To the contrary I often see a very hefty contraction of the stomach starting after the ingestion of food which is often accompanied by burping or the feeling of fullness or even gulping and sometimes vomiting.
So, despite the diagnosis of gastroparesis a strong peristaltic activity of the stomach presses food into the descending portion of the duodenum. Now the food distends the duodenum progressively exerting pressure onto the right renal vein according to the above-described mechanism. Then , only after multiple futile compressions, small amounts of food pass little by little across the aortomesenteric fork. In some patients the fork is relatively tight adding to the pressure in the contracting descending part of the duodenum. In other patients the fork is open but nevertheless a disturbed motor function of the descending part of the duodenum causes the above-described compression of the right renal vein.
In these relatively numerous patients with a disturbed contractile activity of the descending part of the duodenum and subsequent growing pain in the right upper abdomen I often could diagnose a Borna virus infection which is able to hamper a normal peristaltic activity of the duodenum and may be treated after a proper diagnosis with an anti-viral medication.
So, it is crucial to do a meticulous functional ultrasound examination to find the reason for post-prandial pain in the right upper quadrant which cannot be clarified by gastroscopy nor CT nor MRI imaging nor a conventional ultrasound examination.
It is necessary to prove the above-described mechanism by a pre–and post-prandial PixelFlux measurement of the blood flow in the right kidney which shows a deteriorating perfusion of the subcapsular vessels of the right kidney after a meal. This is the consequence of the growing venous counterpressure suppressing the blood flow in the tiny subcapsular vessels of the kidney when the pressure inside the right renal vein grows steadily after a meal.
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